Let’s Celebrate The AMAZING Ivermectin
Launched in 2021, the first World Ivermectin Day raised massive awareness about the life-saving benefits of the medicine Ivermectin including for Covid-19 symptoms and prevention.
You can help us spread critical awareness about Ivermectin this July 23 by joining or hosting an event and sharing information on social media. We will also have a 24-hour video reel bringing you the latest on the story from around the world.
1987- the year Ivermectin was approved for human use!
2015 – the year Ivermectin won the Nobel Prize!
Why we love Ivermectin
How does Ivermectin actually work against COVID-19?
Ivermectin stops SARS-CoV-2 from entering the cells
SARS-CoV-2 enters a cell via the spike-shaped protein on its surface. The protein docks in at the cell’s ACE-2 receptors, and then fuses itself to the cell membrane. Ivermectin prevents this from happening by binding to the virus’ spike protein and to enzymes in the cell membrane.
Ivermectin may stop viral proteins from travelling in and out of the cell nucleus
Ivermectin hitches exactly the same ride, leaving the virus stranded. The virus can’t get into the nucleus – and it can’t stop the cell from releasing Interferon to alert other cells, either.
It prevents viral replication and assembly
Once a virus enters a cell, it hijacks its machinery and instructs it to produce more virus. Ivermectin helps prevent this by binding to some of the enzymes and proteins the virus needs in order to replicate.
Ivermectin reduces inflammation
If Covid-19 progresses, the virus can trigger a hyper-inflammatory response that damages tissue and can lead to organ failure as well as clotting issues including thrombosis. It does this by activating the production of pro-inflammatory proteins called cytokines, via toll-like receptors (TLRs) in the body, and also via a protein called signal transducer and activator of transcription 3 (STAT3). The result is a ‘cytokine storm’.
Ivermectin reduces the production of cytokines in several ways, it:
- Inhibits the signalling of a specific TLR called TLR4 – also blocking the specific pathway downstream of TLR4 that produces cytokines
- Inhibits STAT3
- Suppresses the production of Interleukin-6 (IL6) and Tumour Necrosis Factor Alpha (TNFα), two major components of cytokine storms
- Inhibits HMGB1 – a protein that activates TLR4 – mediating lung inflammation