Welcome to World Ivermectin Day 2023

Let’s Celebrate The AMAZING Ivermectin

Launched in 2021, the first World Ivermectin Day raised massive awareness about the life-saving benefits of the medicine Ivermectin including for Covid-19 symptoms and prevention.

You can help us spread critical awareness about Ivermectin this July 23 by joining or hosting an event and sharing information on social media. We will also have a 24-hour video reel bringing you the latest on the story from around the world.

Key dates:

1987- the year Ivermectin was approved for human use!

2015 – the year Ivermectin won the Nobel Prize!

Ivermectin illustration
This illustrative work, a collotype photograph* made from a scanning electron micrograph of Streptomyces avermectinius (former name S. avermitilis) | Professor Satoshi Omura, Ph.D., M.J.A.

Support WID 2024

We invite you to support our efforts by asking you to donate to World Ivermectin Day today. Your generous contributions ensure that we continue to stand up for what is right. 

Why we love Ivermectin

How does Ivermectin actually work against COVID-19?

SARS-CoV-2 enters a cell via the spike-shaped protein on its surface. The protein docks in at the cell’s ACE-2 receptors, and then fuses itself to the cell membrane. Ivermectin prevents this from happening by binding to the virus’ spike protein and to enzymes in the cell membrane. 

It is hypothesised that, as with other RNA viruses, SARS-CoV-2 hitches a ride on the cell’s protein transport system to get its own proteins into the cell’s nucleus. Once in, it blocks the infected cell’s warning signal – Interferon – so surrounding cells have no idea what’s coming their way. 
Ivermectin hitches exactly the same ride, leaving the virus stranded. The virus can’t get into the nucleus – and it can’t stop the cell from releasing Interferon to alert other cells, either. 

Once a virus enters a cell, it hijacks its machinery and instructs it to produce more virus. Ivermectin helps prevent this by binding to some of the enzymes and proteins the virus needs in order to replicate.

If Covid-19 progresses, the virus can trigger a hyper-inflammatory response that damages tissue and can lead to organ failure as well as clotting issues including thrombosis. It does this by activating the production of pro-inflammatory proteins called cytokines, via toll-like receptors (TLRs) in the body, and also via a protein called signal transducer and activator of transcription 3 (STAT3). The result is a ‘cytokine storm’.
Ivermectin reduces the production of cytokines in several ways, it:

  • Inhibits the signalling of a specific TLR called TLR4 – also blocking the specific pathway downstream of TLR4 that produces cytokines
  • Inhibits STAT3
  • Suppresses the production of Interleukin-6 (IL6) and Tumour Necrosis Factor Alpha (TNFα), two major components of cytokine storms
  • Inhibits HMGB1 – a protein that activates TLR4 – mediating lung inflammation
SARS-CoV-2 also binds to CD147 receptors on red blood cells. It doesn’t enter cells this way, but this mechanism can cause clotting. Ivermectin prevents this by binding to the spike protein.
SARS-CoV-2 can cause acute myocardial injury and chronically damage the cardiovascular system of those actively infected as well as those with long Covid. Ivermectin can improve cardiac function by increasing mitochondrial ATP production, even under hypoxic conditions.
Decreased Bifidobacteria levels are observed in people susceptible to Covid-19, for example, in the elderly and in the obese. Ivermectin, as a by-product of Streptomyces fermentation, may increase Bifidobacteria in the gut, which may assist in boosting natural immunity to Covid-19.
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